All these features have been described for follicular lesions or neoplasia together with occasional nuclear grooves, as occurred in two (25%) of the studied cases. Correlation of cytologic and histologic features in variants of papillary carcinoma of the thyroid. Privacy, Help Background. Unable to load your collection due to an error, Unable to load your delegates due to an error. The cells were arranged mainly in monolayer sheets and syncytial fragments; occasional microfollicle formation with abundant fine eosinophilic cytoplasm was seen. 1 This paradox is attributed to the fact that we are diagnosing many more nonfatal cases, of which most are minimally invasive and minimally malignant tumors. Micropatterned growth surface topography affects extracellular vesicle production. This site needs JavaScript to work properly. Follicular variant of papillary carcinoma is a common type of papillary thyroid cancer. Thyroid nodules with FNA cytology suspicious for follicular variant of papillary thyroid carcinoma: Follow‐up and management Sanjay Logani M.D. To evaluate the role of ultrasonography (US), US-guided fine-needle aspiration (USFNA) and intraoperative frozen section (FS) in follicular neoplasm. The criteria for classification of well-differentiated thyroid carcinoma have changed from an emphasis on the histologic pattern of cellular architecture to a focus on the cytologic features characteristic of papillary and follicular carcinoma … Only 5 cases showed prominent nuclear features of papillary carcinoma. FOIA Although true follicular thyroid carcinoma is known to metastasize via the bloodstream and give rise to bone and lung metastases, such a pattern of spread is rare in papillary thyroid carcinoma. However, the follicular variant of papillary thyroid carcinoma(FVPTC) poses a diagnostic challenge. Background: The cytological discrimination between benign and malignant follicular-patterned lesions of the thyroid can represent a diagnostic challenge, even for experienced pathologists. Accessibility Introduction. US features, USFNA cytology, and FS results were compared based on the pathology results of patients with Author information: (1)Pathology Service, Dr. A. Onativia Endocrinology and Metabolism Hospital, Salta, Argentina. 2010; 23: 1191 – 1200 On the contrary, reported sensitivity of FNA in FVPTC is significantly low [ … Careers. 8600 Rockville Pike An electron-microscopic study of human thyroid cancer. Preoperative features on ultrasound (US) imaging are different between follicular PTC and classic PTC. 1979 Oct-Dec;17(4):233-9. An analysis of trends of incidence and cytohistological correlation of papillary carcinoma of the thyroid gland with evaluation of discordant cases. Fine needle aspirates from 8 thyroid papillary carcinomas, follicular variant, were studied. There are several studies on the cytologic clues improving the diagnostic accuracy. Oxford University Press is a department of the University of Oxford. Nuclear cytoplasmic inclusions occurred in seven (87.5%) of the cases. Fine needle aspirates from 8 thyroid papillary carcinomas, follicular variant, were studied. 3 A dense globule of colloids of follicular variant papillary thyroid carcinoma. Harach HR(1), Zusman SB. In the other six (75%) cases, a moderate to high proportion of neoplastic cells with nuclear grooves facilitated the diagnosis of papillary carcinoma. Background: Fine needle aspiration cytology (FNAC) is an important investigation in preoperative diagnosis of thyroid lesions. Nuclear enlargement was a consistent finding in all cases. The follicular variant of papillary thyroid carcinoma: characteristics of preoperative ultrasonography and cytology Follicular variant of papillary carcinoma thyroid (FVPTC) is a well defined entity in histopathology, but its diagnosis in FNAC is usually missed and is challenging compared to classic papillary thyroid carcinoma. The follicular variant of papillary carcinoma can be difficult to distinguish from a follicular lesion; the chromatin pattern can be helpful. Copyright © 2021 American Society for Clinical Pathology. Cribriform-morular variant of papillary carcinoma: a distinctive variant representing the sporadic counterpart of familial adenomatous polyposis-associated thyroid carcinoma? follicular variant of papillary thyroid carcinoma (FVPTC) is the second most common variant; these variants comprise approximately 55%-66% and 11.8%-31.6% of well differentiated thyroid carcinomas, respectively [1-5]. J Cytol. Hemosiderin laden macrophages and hemosiderin within follicular cells distinguish benign follicular lesions from follicular neoplasms. Department of Pathology and Laboratory Medicine . 2 The 2, 3 It was recently renamed as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) because of its unique behavior and good … Interobserver variation in the Follicular variant PTC was considered to be present in cases of PTC showing a follicular growth pattern with virtually no papillary structures along with nuclear features of papillary carcinoma. All cases showed increased cellularity and a background of moderate to abundant thin watery colloid with variable amounts of thick eosinophilic colloid. Cystic changes in primary tumor or in metastasis are not infrequent. conventional papillary carcinoma (55-60%) and follicular variant papillary thyroid carcinoma (FVPTC, 23-41%).8 The neoplasm had a follicu-lar architectural pattern but the nuclear features were that of the conventional PTC.9 The recogni-tion of the FVPTC posed many problems at different levels. Fine-Needle Aspiration Cytology of Noninvasive Follicular Variant of Papillary Thyroid Carcinoma Is Cytomorphologically Distinct From the Invasive Counterpart. Would you like email updates of new search results? Am J Clin Pathol. Cytologic findings in the follicular variant of papillary carcinoma of the thyroid. Biopsy of the scalp swelling and thyroid nodule confirmed the same. Cytojournal. Zubair W. Baloch, MD, PhD, Prabodh K. Gupta, MD, FIAC, Gordon H. Yu, MD, Martha J. Sack, MD, Virginia A. LiVolsi, MD, Follicular Variant of Papillary Carcinoma: Cytologic and Histologic Correlation, American Journal of Clinical Pathology, Volume 111, Issue 2, 1 February 1999, Pages 216–222, https://doi.org/10.1093/ajcp/111.2.216. Diff-Quik staining, ×20 magnification Fig. Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns. The follicular variant of papillary thyroid carcinoma (FVPC) is now recognized as a distinct subtype of papillary thyroid carcinoma (PC) (1., 2., 3., 4., 5. 1 - 8 In Diff‐Quik (Baxter Diagnostics, McGaw Park, IL)‐stained smears of 63 cases of FVPC, Gallagher et al. noninvasive encapsulated follicular variant of papillary thyroid cancer (EFVPTC) The cytologic diagnosis of follicular variant of papillary thyroid carcinoma (FVPTC) can be difficult owing to the paucity of nuclear changes of papillary carcinoma and overlapping features with other follicular-de rived lesions. Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns. Authors: Ashley A Ibrahim, MD . This morphologic heterogeneity explains the variability seen in FNA specimens of FVPTC and may result in false-negative diagnoses. Fig. Synthesis and characterization of magnesium diboride nanosheets in alginate/polyvinyl alcohol scaffolds for bone tissue engineering. 2016; 146(3):373-7 (ISSN: 1943-7722) Ibrahim AA; Wu HH World J Surg. 2010;23(9):1191-1200.Google Scholar Crossref Colloid material presented as intraluminal (one case) or extraluminal, dense, round masses (six cases). In this study, we aimed to compare functional status, ultrasonographical features, cytological results, and histopathological characteristics of patients with CPTC and FVPTC. Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid gland [1,2], and numerous variants of PTC have been reported with distinct histopathological features [].Conventional or classical PTC is the most frequent type, while the follicular variant of papillary thyroid carcinoma (FVPTC) is the second most common variant; … For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Nuclear grooves in the aspiration cytology of papillary carcinoma of the thyroid. Follicular variant papillary thyroid carcinoma (FVPTC) is the most common variant of papillary thyroid carcinoma (PTC) after classical PTC (CPTC). Ultrasonography (2016-01-01) . 1 At the same time, however, disease mortality has remained constant. Ultrasound-guided fine-needle aspiration biopsy (FNAB) is the recommended modality for the evaluation of suspicious thyroid nodules. Methods. The goal of this study is to evaluate … From the Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia. Search for other works by this author on: © American Society for Clinical Pathology. Dear Dr. Bedrossian, Being the most common neoplasm of the thyroid gland, papillary thyroid carcinoma (PTC) is the thyroid carcinoma that has been searched most and has had most number of variant. Division of Cytopathology, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
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