Metaplastic carcinoma includes a group of neoplasms characterized by differentiation of the neoplastic epithelium into squamous cells and/or mesenchymal-looking elements, in addition to epithelial components, elements such as cartilage, bone tissue, myxoid stroma, or rhabdomyoid cells. 2007 Jun;35(6):313-8. doi: 10.1002/dc.20639. One of these cases showed a peculiar mixture of malignant ductal, apocrine type, and squamous epithelial cells with fascicles of spindle cells with variable degree of atypia and was diagnosed as metaplastic carcinoma of the carcino … Three cases of metaplastic carcinoma of breast are presented. In general, these tumours are firm, nodular, and tend to be well circumscribed. Carcinosarcoma of Breast Mimicking Breast Abscess. Working off-campus? Privacy, Help Metaplastic carcinoma of breast with osteosarcomatous differentiation: A rare case diagnosed by fine needle aspiration cytology International Meeting on Clinical Case Reports April 18-20, 2016 Dubai, UAE. Diagn Cytopathol. INTRODUCTION Metaplastic carcinoma is a heterogeneous group of breast malignancies characterized by a mixture of epithelial and mesenchymal elements'. Epub 2006 Jun 23. Metaplastic carcinomas of the breast are defined by mesenchymal and/or squamous cell components associated with ductal carcinoma and may raise diagnostic problems in FNA cytology. Metaplastic carcinoma of the breast is a rare malignant neoplasm comprised of ductal, squamous and/or mesenchymal elements in various proportions. One of these cases showed a peculiar mixture of malignant ductal, apocrine type, and squamous epithelial cells with fascicles of spindle cells with variable degree of atypia and was diagnosed as metaplastic carcinoma of the carcino-sarcomatous type. BACKGROUND Metaplastic carcinomas of the breast are uncommon, and most display marked cellular atypia. Background: Metaplastic carcinoma of the breast encompasses a heterogeneous group of tumours with variable components of sarcomatoid, squamous or poorly differentiated carcinomas. Metaplastic breast carcinoma: pathology and clinical outcome. Please enable it to take advantage of the complete set of features! There are limitations in fine-needle aspiration diagnosis due to its pathological heterogeneity. Both these latter cases were defined as matrix-producing metaplastic carcinomas. Fine-needle aspiration cytology of medullary breast carcinoma: report of two cases and review of the literature with emphasis on differential diagnosis. Metaplastic carcinoma can … Metaplastic Carcinoma of the Breast. Because metaplastic carcinoma of the breast encompasses a great variety of histopathology, diagnostic challenges abound, especially within the realm of cytology. Please check your email for instructions on resetting your password. Metaplastic carcinoma is a rare, triple-negative carcinoma of the breast that exhibits transformation of part or all of its glandular carcinomatous component into a nonglandular, or metaplastic, component. Spindle cell carcinoma is a variant of metaplastic carcinoma with predominance of spindle cells (WHO Classification - 8070/3) [, , ].Metaplastic carcinoma of the breast is a heterogeneous group of rare neoplasm and it includes tumor with mixed carcinomatous and sarcomatoid (biphasic), or with sarcomatoid component alone (monophasic) [5,6]. The unusual metaplastic carcinomas have a variety of names, each emphasizing the dominant histologic pattern. The difficulties found on fine needle aspiration cytology and the limitations of this procedure are discussed as well the main features of this tumor. Mammogram was reported as suspicious for malignancy. Fine-needle aspiration cytology of metaplastic carcinoma of the breast. Because metaplastic carcinoma of the breast encompasses a great variety of histopathology, diagnostic challenges abound, especially within the realm of cytology. Metaplastic breast carcinoma (MBC) may have a varied presentation on fine-needle cytology samples. Components may include features of ductal, spindle, or squamous carcinoma with... Metaplastic carcinoma of the breast—diagnosis by aspiration biopsy cytology: Report of two cases and literature review - Kline - 1990 - Diagnostic Cytopathology - Wiley Online Library The lesion affected a 68-yr-old woman, with a tumor measuring 6.4 x 5.3 cm well demarcated mass located in the upper outer quadrant of the right breast. Accurso A, Ciancia G, Della Corte GA, Reale P, Accardo G, Salerno C, Bordoni D, Falco G, Rocco N. Int J Surg Case Rep. 2016;21:125-8. doi: 10.1016/j.ijscr.2016.03.004. Metaplastic carcinomas of the breast—fine needle aspiration (FNA) cytology findings Metaplastic carcinomas of the breast are defined by mesenchymal and/or squamous cell components associated with ductal carcinoma and may raise diagnostic problems in FNA cytology. When it develops under p … Breast surgery, neoadjuvant or adjuvant treatment, clinic-pathological factors, number and type of events during follow … Castellà E, Gómez-Plaza MC, Urban A, Llatjós M. Diagn Cytopathol. The authors compiled and studied an eight-case series comprised of metaplastic breast carcinomas and lesions initially suspicious cytologically for metaplastic carcinoma in order to assess the degree of cytologic … The cell‐rich aspirate reveals benign multinucleated giant cells intermingled with malignant spindled or squamous cells on a background of necrotic debris, inflammatory cells, and blood. Metaplastic breast carcinoma (MBC) may have a varied presentation on fine-needle cytology samples. Bethesda, MD 20894, Copyright Several interesting observations can be made in the cytological assessment of this series of metaplastic carcinoma. Discussion. 3. Cytopathological features of matrix-producing carcinoma of the breast. The breast neoplasm has a characteristic pattern on aspiration biopsy cytology (ABC). 2018 Sep;9(3):398-401. doi: 10.1007/s13193-018-0777-z. Components may include features of ductal, spindle, or squamous carcinoma with pseudosarcomatous, cartilaginous, or boney areas. 2007 May;60(5):529-33. doi: 10.1136/jcp.2006.039412. We herewith describe three cases of MBC found in our series. Diagn Pathol. Recently, a low grade fibromatosis-like metaplastic carcinoma was found and displayed little nuclear atypia. Lui PC, Tse GM, Tan PH, Jayaram G, Putti TC, Chaiwun B, Chan NH, Lau PP, Mak KL, Khin AT. and you may need to create a new Wiley Online Library account. We report a case of metaplastic breast carcinoma (MBC) in whom fine-needle aspiration (FNA) cytology was performed with later histological confirmation. 2008 May;109(2):199-207. doi: 10.1007/s10549-007-9652-2. At low magnification a pattern somewhat similar to fibroadenoma. If you do not receive an email within 10 minutes, your email address may not be registered, In breast pathology, the distinction between matrix-producing metaplastic carcinoma (MPMC) and pleomorphic adenoma (PA) is sometimes unclear especially on core needle biopsy . 343 The average age of patients is over 50years old, similar to classic infiltrating ductal carcinoma. All seven cases contained foci of ductual adenocarcinoma. The breast neoplasm has a characteristic pattern on aspiration biopsy cytology (ABC). Two cases of matrix-producing carcinoma showing chondromyxoid matrix in cytological specimens. 14,16,17,18,19. Careers. There are rare reports of metaplastic carcinoma associated with lobular, medullary, mucinous and tubular carcinoma; Richard L Kempson MD Robert V Rouse MD [citation needed] Epub 2016 Mar 10. A wide range of extramammary malignancies can metastasize to the breast, including lymphoma, melanoma, sarcoma (uterine leiomyosarcoma, rhabdomyosarcoma, liposarcoma) and carcinoma (common primary sites include gynecologic, lung, gastrointestinal, genitourinary, head and neck) (Cancer 2007;110:731, Mod Pathol 2013;26:343) A few reports from individual tumors examined by fine-needle aspiration biopsy have emphasized an array of findings. Epub 2018 May 19. Few cases of metaplastic carcinoma of the breast have been reported in the cytological literature'. Top of the differential diagnosis for spindle cell lesions of the breast. Metaplastic carcinoma of the breast encompasses a heterogeneous group of tumours with variable components of sarcomatoid, squamous or poorly differentiated carcinomas. This finding was combined with heterologous mesenchymal elements in four cases, a spindlecell pattern of growth in one case, and extensive squamous‐cell metaplasia in two cases. Epub 2007 Jul 18. A rare case of true carcinosarcoma of the breast. J Clin Pathol. Int J Clin Exp Med. Learn more. J Cytol. Components may include features of ductal, spindle, or squamous carcinoma with pseudosarcomatous, cartilaginous, or boney areas. Immediate evaluation improves the potential of making the correct diagnosis and determines optimum sample management by indicating the need for additional tissue and the ancillary tests to be undertaken for an accurate diagnosis, including microbiology for an inflammatory specimen, flow cytometry for a predominantly lymphoid specimen, and breast cancer markers to be performed on the formalin-fixed, paraffin-embedded specimen in cases of carcinoma.
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