2021 Mar 2;11(3):418. doi: 10.3390/diagnostics11030418. Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignant tumours, accounting for up to 80% of overall cases [].Although most of them belong to the so-called classic phenotype, several variants have been described and currently classified according to the WHO classification [].In particular, a group of these variants features … National Library of Medicine Careers. Because the 10-year disease-free survival rate is >95%,1, 2 the practical issue for PTC patients focuses on prediction of disease recurrence. Cancer 66:2306–2312 PubMedCrossRef Fujimoto Y, Obara T, Ito Y et al (1990) Diffuse sclerosing variant of papillary carcinoma of the thyroid. The insular variant type was found to be the most dangerous, with the lowest survival rate, followed by poorly differentiated thyroid cancer, tall cell variant and, least dangerous, diffuse sclerosing variant. A short summary of this paper. The diffuse sclerosing variant of PTC predominantly observed in young patients is a rare aggressive tumor that requires intensive treatment. Tunca F, Sormaz IC, Iscan Y, Senyurek YG, Terzioglu T. J Endocrinol Invest. 2020 Dec;35(4):696-715. doi: 10.3803/EnM.2020.807. Risk of recurrence in a homogeneously managed pT3-differentiated thyroid carcinoma population. The only prognostic factor for recurrence in the multivariate analysis was extranodal extension (odds ratio 3.4 [1.1; 10.8]). The authors analyzed data from a total of 170,778 patients, including 162,827 (95.3%) with classic papillary thyroid cancer and 7951 (4.7%) with aggressive variant papillary thyroid cancer. Classically, PTC has been classified as a well-differentiated thyroid cancer, together with follicular thyroid cancer, because of its good prognosis and low mortality rate. Introduction. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Conclusion: However, the clinical behaviors of this cancer are complex and varied. Privacy, Help Tumor size independently predicted worse prognosis for TCV (HR 1.29, P < 0.001) but not DSV patients. The histologic types of thyroid carcinoma were papillary thyroid carcinoma (PTC) in 57 (83.8%), follicular carcinoma in 8 (11.8%), and poorly differentiated carcinoma in 3 (4.4%). Thyroid cancer is usually curable. Clinicopathologic features and outcomes in patients with diffuse sclerosing variant of papillary thyroid carcinoma. Despite aggressive surgical approaches, the recurrence rate within the first 5 years … Routine radioiodine ablation therapy after initial surgery was not performed unless distant metastasis was clinically apparent at surgery. Clinicopathologic features and outcomes in patients with diffuse sclerosing variant of papillary thyroid carcinoma. Papillary Thyroid Carcinoma Tissue miR-146b, -21, -221, -222, -181b Expression in Relation with Clinicopathological Features. 3. The majority of PTCs are effectively treated using a combination of surgical and radioiodine-based therapies, with associated 20-year cause-specific survival rates exceeding 90% 4 . In fact, the overall rate of survival for people diagnosed with diffuse sclerosing variant was similar to those diagnosed with classical papillary thyroid cancer, suggesting that the diffuse sclerosing variant … Despite aggressive surgical approaches, the recurrence rate within the first 5 years requires a careful ongoing surveillance, similar to the follow-up of high-risk PTC patients. The RFS was significantly worse in patients with DSV than in other PTC patients (hazard risk 8.5 [5.2; 13.9], P < .0001) and were similar to the RFS of high-risk PTCs (hazard risk 1.1 [0.6; 2.2], P = .5). Materials and methods: Excluding patients with microcarcinoma, 5848 patients with PTC underwent initial surgery between 1995 and 2011. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L. Thyroid. Overall, the prevalence of DSVPTC varies from 0.7–6.6% of all papillary thyroid … The 5-year and 10-year cancer-specific survival rates were significantly lower in the DSV group (97.6% and 97.6%, respectively). Aggressive Papillary Thyroid Carcinoma: Update on Incidence and Survival Outcomes. Unable to load your collection due to an error, Unable to load your delegates due to an error. 2018 May;403(3):325-332. doi: 10.1007/s00423-018-1657-2. The histopathology analysis of the diffuse sclerosing variant of the papillary carcinoma of the thyroid: A distinctive and rare form. Medicine (Baltimore). Although the prognosis of PTC is always excellent with a 10-year survival rate over 90%, some patients suffer tumor recurrence and even death ().In the past few decades, several histologic variants including diffuse sclerosis variant (DSV) and tall … We investigated biological behaviors and prognoses of DSV in 35 patients who underwent surgical treatment between 1989 and 2007. Associated with a shorter disease free survival; however, the overall mortality rate is similar to that of conventional PTC with disease specific survival of 95% and 93% at 5 and 10 years, respectively (possibly due to younger patient age and aggressive initial treatment) (Ann Surg Oncol 2006;13:176, Endocr Pathol 2005;16:331, World J Surg 2009;33:958, World J Surg 2015;39:1728) PAPILLARY thyroid carcinoma (PTC) is the most common variety of thyroid cancer (70%-80% of cases) and the most common endocrine neoplasia. FVPTC patients have a better survival rate than those with follicular thyroid cancer, and fewer instances of lymph node or soft tissue invasion than control patients with classical PTC. Diffuse sclerosing variant papillary thyroid carcinoma (DSVPTC) is an uncommon variant of papillary thyroid carcinoma (PTC). Privacy, Help Diffuse Sclerosing Variant of Papillary Carcinoma of the thyroid (DSVPC) is a rare . Clinical importance, surgical treatment, and follow-up study. Research conducted by Allen S. Ho, MD, of Samuel Oschin Comprehensive Cancer Institute, Los Angeles, and colleagues reported a significant increase in the incidence of aggressive papillary thyroid carcinoma, resulting in a wide variety of survival … 2016 Aug;5(2):333-336. doi: 10.3892/mco.2016.932. DSV patients share the same recurrence rate as high-risk PTC patients. Jeong SH, Hong HS, Lee EH, Kwak JJ. 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. Prevention and treatment information (HHS). In patients with PTC, there was a higher incidence of bilateral thyroid involvement (p = 0.003), extrathyroidal extension (p = 0.009), and lymph node involvement (p = 0.018), and lower recurrence-free survival (p = 0.032) in DSVPC than in non-DSVPC. Diffuse Sclerosing Variant of Papillary Carcinoma of the thyroid (DSVPC) is a rare variant of Papillary Thyroid Cancer (PTC). The aim of this systematic review and meta-analysis is to investigate the prognostic significance and outcomes of DSVPTCs in comparison … Presenting with Brain Metastases. Among 37 cases of DSV-PTC, 17 were positive for RET/PTC1 (46%), six for RET/PTC3 (16%) and nine for … Background: Would you like email updates of new search results? The diffuse sclerosing variant of papillary thyroid cancer presenting as innumerable diffuse microcalcifications in underlying adolescent Hashimoto's thyroiditis: a case report. The 7-year recurrence-free survival (RFS) was 63%. Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer, and an excellent overall survival rate. Diffuse sclerosing variant (DSV) is a variant of papillary thyroid carcinoma that has diffuse involvement in one or both thyroid lobes without forming a dominant mass. Papillary thyroid carcinoma (PTC), the most common thyroid cancer, has the highest increase in incidence of any cancer and is postulated to soon become the third most common cancer among women [].Despite this incremental increase in its incidence rate, PTC largely remains of an indolent nature and a favorable prognosis, with most patients having a 5-year overall survival rate … 02/10/2020 - Most thyroid cancer is easily treated but people who are diagnosed after age 55 are more likely to face recurrent cancer than those diagnosed at a younger age. The histologic types of thyroid carcinoma were papillary thyroid carcinoma (PTC) in 57 (83.8%), follicular carcinoma in 8 (11.8%), and poorly differentiated carcinoma in 3 (4.4%). Conclusion: DSVPTCs should be considered high-risk PTCs because of high propensity for tumor invasion, metastasis, relapse and mortality. Differentiated thyroid cancer is the most common endocrine malignancy and most are papillary thyroid carcinomas (PTCs). Twenty-two patients (0.4 %) were histologically diagnosed with DSV, of whom 20 (91 %) were <45 years old. Fifty-six DSV patients were included (mean age 32.6 ± 12.5 y; 46 [82%] female) and were compared with 2945 non-DSV PTCs and 48 high-risk PTCs. Introduction. Therefore, DSV requires careful surgical resection to minimize the carcinoma recurrence. Unable to load your collection due to an error, Unable to load your delegates due to an error. Careers. Department of Radiology, University of Iowa Hospitals and Clinics, USA. Experience in 25 Patients. The data of patients who underwent surgery for DSV and PTC between 2003 and 2014 in seven surgical departments specialized in endocrine surgery were reviewed. The 7-year recurrence-free survival (RFS) was 63%. -, Thyroid. Kondrotienė A, Daukša A, Pamedytytė D, Kazokaitė M, Žvirblienė A, Daukšienė D, Simanavičienė V, Klimaitė R, Golubickaitė I, Stakaitis R, Šarauskas V, Verkauskienė R, Žilaitienė B. Diagnostics (Basel). However, some of its variants, such as tall cell and insular variants, may be more aggressive. tall cell, diffuse sclerosing, or columnar cell variants). The aim of this systematic review and meta-analysis is to investigate the prognostic significance and outcomes of DSVPTCs in comparison with classical PTCs (cPTCs). 2017 Apr;176(4):433-441. doi: 10.1530/EJE-16-0863. Differentiated thyroid cancer is the most common endocrine malignancy and most are papillary thyroid carcinomas (PTCs). Download Full PDF Package. There are 45,000 cases in the United States every year and this … Would you like email updates of new search results? Diffuse sclerosing variant (DSV) is a rare and aggressive subtype of papillary thyroid carcinoma (PTC). Introduction. … Diffuse Sclerosing Variant of Papillary Carcinoma of the thyroid (DSVPC) is a rare variant of Papillary Thyroid Cancer (PTC). 2021 Mar;10(3):1147-1153. doi: 10.21037/gs-20-815. A systematic review and meta-analysis by … Papillary carcinoma is the most common type of thyroid carcinoma accounting for approximately 70% of total cases of thyroid carcinoma; however, it only accounts for 1% of overall cancers in the US. Epub 2018 Jun 16. THYROID CANCER AND NODULES Diffuse Sclerosing Variant Is a Major Subtype of Papillary Thyroid Carcinoma in the Young ... with an overall survival rate … Diffuse sclerosing variant of PTC (DSV PTC) is an uncommon variant of PTC highly prevalent in female pediatric / young patients and in patients with history of radiation exposure. Updates in the Pathologic Classification of Thyroid Neoplasms: A Review of the World Health Organization Classification. Clinical importance, surgical treatment, and follow-up study. For those elderly PTMC patients, the effectiveness of prophylactic cervical lymph node dissection (CLND) continues to be debated for the lack of randomized controlled data [11,12] Studies have shown … Prognostic importance of sclerosing variant in papillary thyroid carcinoma. We investigated the biological characteristics of DSV in Japan. It is more common in women with an M:F ratio of 1:2.5 (range 1:1.6-3:1) . Context: Background: Diffuse sclerosing variant (DSV) of papillary thyroid carcinoma (PTC) is a rare variant more common among younger patients. 2005 Jul;29(7):917-20 When papillary carcinoma develops on top of Hashimoto thyroiditis, the disease tends to be less aggressive … It was rstly described by Vicky et al. Diffuse sclerosing papillary thyroid carcinoma (DSPTC) is an uncommon variant of papillary thyroid carcinoma. After adjustment, DSV [hazard ratio (HR) 1.8, P = 0.007] and TCV (HR 1.9, P < 0.001) histologies were associated with significantly reduced survival (5-year overall: 87.5% DSV, 80.6% TCV vs. 93.5% PTC, P < 0.001). FOIA Some studies suggest that the diffuse sclerosing variant of papillary thyroid cancer … Diffuse sclerosing variant (DSV) of papillary thyroid carcinoma (PTC) is a rare variant more common among younger patients. The aim of this study was to analyze the clinicopathologic features of a large cohort of patients with this disease. Papillary carcinomas usually presents as solitary thyroid … To date, it is unclear if these subtypes are also rising in frequency and if there are really more dangerous. Spinelli C, Strambi S, Bakkar S, Nosiglia A, Elia G, Bertocchini A, Calani C, Leoni M, Morganti R, Materazzi G. World J Surg. Approximately 10-15% of patients have metastases to lymph nodes or (more rarely) lung at the time of presentation; however, the prognosis is excellent with a mortality rate of 5% (2). PTC is easy to spread via lymphatic ducts, which results in recurrence, metastases, and even death The disease-free … PTC is the most common form of malignancy associated with HT. Please enable it to take advantage of the complete set of features! Design and setting: Most papillary carcinomas are diagnosed between the ages of 20 and 50 years old. The aim of the present study was to retrospectively evaluate the clinicopathologic features and outcomes in a series … 2017 Apr;36(2):103-110. doi: 10.14366/usg.16048. Despite characteristic clinical and histological features that facilitate easy … This site needs JavaScript to work properly. tall cell, diffuse sclerosing, or columnar cell variants). There are a number of important questions about these uncommon, more aggressive thyroid cancer subtypes that remain to be answered. Case Report. However, there was no significant difference in overall survival rate between these groups for patients without invasive disease, if the data …
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